Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

FcRn anticorps

FcRn Reactivité: Humain ELISA, IF, FACS, cELISA Hôte: Souris Monoclonal DVN24 unconjugated
N° du produit ABIN1774763
  • Highlights
    • Anticorps FcRn de haute qualité (Clone DVN24) pour la détection de FcRn.
    • Hautement spécifique du FcRn humain, bloque la liaison de l'IgG.
    • PBS-only, preservative free.
    • 2 références PubMed disponibles pour cet anticorps FcRn.
    Antigène Voir toutes FcRn Anticorps
    FcRn (IgG receptor FcRn (FcRn))
    Reactivité
    • 42
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 39
    • 8
    • 1
    Souris
    Clonalité
    • 40
    • 8
    Monoclonal
    Conjugué
    • 23
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FcRn est non-conjugé
    Application
    • 30
    • 27
    • 8
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Cell-ELISA (cELISA)
    Attributs du produit
    based on recognition of the complete native protein expressed on transfected mammalian cells
    Purification
    Purified, Protein G
    Immunogène
    hFcRn
    Clone
    DVN24
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product FcRn Anticorps primaire
  • Indications d'application
    Flow cytometry: 1.2 μg/10^6 cells ELISA: 1:200 - 1:400CELISA: 1:200 - 1:400For each application a titration should be performed to determine the optimal concentration.
    Restrictions
    For Research Use only
  • Buffer
    PBS pH 7.2
    Conseil sur la manipulation
    avoid repeated freezing and thawing
    Stock
    4 °C
  • Xu, He, Momben-Abolfath, Vertrees, Li, Norton, Struble: "Zika Virus Infection and Antibody Neutralization in FcRn Expressing Placenta and Engineered Cell Lines." dans: Vaccines, Vol. 10, Issue 12, (2022) (PubMed).

    Hubbard, Pyzik, Rath, Kozicky, Sand, Gandhi, Grevys, Foss, Menzies, Glickman, Fiebiger, Roopenian, Sandlie, Andersen, Sly, Baker, Blumberg: "FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity." dans: The Journal of experimental medicine, Vol. 217, Issue 10, (2021) (PubMed).

    Cines, Zaitsev, Rauova, Rux, Stepanova, Krishnaswamy, Sarkar, Kowalska, Zhao, Mast, Blumberg, McCrae, Poncz, Hubbard, Pyzik, Blumberg: "FcRn augments induction of tissue factor activity by IgG-containing immune complexes." dans: Blood, Vol. 135, Issue 23, pp. 2085-2093, (2021) (PubMed).

    Grevys, Nilsen, Sand, Daba, Øynebråten, Bern, McAdam, Foss, Schlothauer, Michaelsen, Christianson, Roopenian, Blumberg, Sandlie, Andersen: "A human endothelial cell-based recycling assay for screening of FcRn targeted molecules." dans: Nature communications, Vol. 9, Issue 1, pp. 621, (2018) (PubMed).

    Christianson, Sun, Akilesh, Pesavento, Proetzel, Roopenian: "Monoclonal antibodies directed against human FcRn and their applications." dans: mAbs, Vol. 4, Issue 2, pp. 208-16, (2014) (PubMed).

    Sand, Dalhus, Christianson, Bern, Foss, Cameron, Sleep, Bjørås, Roopenian, Sandlie, Andersen: "Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies." dans: The Journal of biological chemistry, Vol. 289, Issue 24, pp. 17228-39, (2014) (PubMed).

  • Antigène
    FcRn (IgG receptor FcRn (FcRn))
    Abstract
    FcRn Produits
    Synonymes
    anticorps FCRN, anticorps alpha-chain, anticorps FcRn, anticorps Fc fragment of IgG receptor and transporter, anticorps Fc receptor, IgG, alpha chain transporter, anticorps FCGRT, anticorps Fcgrt
    Sujet
    The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
    Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT
    UniProt
    P55899
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Vous êtes ici:
Support technique