FcRn
Reactivité: Humain
WB, IF
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Flow cytometry: 1.2 μg/10^6 cells br>ELISA: 1:200 - 1:400 br>CELISA: 1:200 - 1:400 br>For each application a titration should be performed to determine the optimal concentration.
Restrictions
For Research Use only
Buffer
PBS pH 7.2
Conseil sur la manipulation
avoid repeated freezing and thawing
Stock
4 °C
Xu, He, Momben-Abolfath, Vertrees, Li, Norton, Struble: "Zika Virus Infection and Antibody Neutralization in FcRn Expressing Placenta and Engineered Cell Lines." dans: Vaccines, Vol. 10, Issue 12, (2022) (PubMed).
Hubbard, Pyzik, Rath, Kozicky, Sand, Gandhi, Grevys, Foss, Menzies, Glickman, Fiebiger, Roopenian, Sandlie, Andersen, Sly, Baker, Blumberg: "FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity." dans: The Journal of experimental medicine, Vol. 217, Issue 10, (2021) (PubMed).
Grevys, Nilsen, Sand, Daba, Øynebråten, Bern, McAdam, Foss, Schlothauer, Michaelsen, Christianson, Roopenian, Blumberg, Sandlie, Andersen: "A human endothelial cell-based recycling assay for screening of FcRn targeted molecules." dans: Nature communications, Vol. 9, Issue 1, pp. 621, (2018) (PubMed).
Christianson, Sun, Akilesh, Pesavento, Proetzel, Roopenian: "Monoclonal antibodies directed against human FcRn and their applications." dans: mAbs, Vol. 4, Issue 2, pp. 208-16, (2014) (PubMed).
Sand, Dalhus, Christianson, Bern, Foss, Cameron, Sleep, Bjørås, Roopenian, Sandlie, Andersen: "Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies." dans: The Journal of biological chemistry, Vol. 289, Issue 24, pp. 17228-39, (2014) (PubMed).
anticorps FCRN, anticorps alpha-chain, anticorps FcRn, anticorps Fc fragment of IgG receptor and transporter, anticorps Fc receptor, IgG, alpha chain transporter, anticorps FCGRT, anticorps Fcgrt
Sujet
The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics. Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT