FcRn anticorps
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- Highlights
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- Anticorps FcRn de haute qualité (Clone DVN24) pour la détection de FcRn.
- Hautement spécifique du FcRn humain, bloque la liaison de l'IgG.
- 2 références PubMed disponibles pour cet anticorps FcRn.
- Antigène Voir toutes FcRn Anticorps
- FcRn (IgG receptor FcRn (FcRn))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp FcRn est non-conjugé
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Application
- ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Cell-ELISA (cELISA)
- Attributs du produit
- based on recognition of the complete native protein expressed on transfected mammalian cells
- Purification
- Purified, Protein G
- Immunogène
- hFcRn
- Clone
- DVN24
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product FcRn Anticorps primaire
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- Indications d'application
- Flow cytometry: 1.2 μg/10^6 cells br>ELISA: 1:200 - 1:400 br>CELISA: 1:200 - 1:400 br>For each application a titration should be performed to determine the optimal concentration.
- Restrictions
- For Research Use only
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- Buffer
- PBS pH 7.2
- Conseil sur la manipulation
- avoid repeated freezing and thawing
- Stock
- 4 °C
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- Antigène
- FcRn (IgG receptor FcRn (FcRn))
- Abstract
- FcRn Produits
- Synonymes
- anticorps FCRN, anticorps alpha-chain, anticorps FcRn, anticorps Fc fragment of IgG receptor and transporter, anticorps Fc receptor, IgG, alpha chain transporter, anticorps FCGRT, anticorps Fcgrt
- Sujet
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The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT - UniProt
- P55899
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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