Complement C8 anticorps

N° du produit ABIN181126

Détail du produit anti-Complement C8 anticorps

Antigène: Complement C8 (C8)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Complement C8 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in blood serum.

Réactivité croisée (Details): Species reactivity (tested):Human.

Attributs du produit: Synonyms: Complement component C8, Complement 8

Purification: Affinity Chromatography on Protein A

Immunogène: Purified Human C8. Genename: C8

Clone: 056B-373

Isotype: IgG1

Information d'application

Indications d'application: ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on Frozen Sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Borate buffered saline pH 8.2-8.4 containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur Complement C8

Antigène: Complement C8 (C8)

Autre désignation: Complement C8 (C8 Produits)

Sujet: C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 Molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane. Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.Synonyms: Complement 8, Complement component C8

ID gène: 732

UniProt: P07358