SIGLEC10 anticorps

N° du produit ABIN1819172

Détail du produit anti-SIGLEC10 anticorps

Antigène: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SIGLEC10 est non-conjugé

Application: Flow Cytometry (FACS)

Specificité: Clone 5G6 specifically recognizes human Siglec-10 (Sialic acid-binding Ig-like lectin 10), a putative adhesion molecule and member of the Ig superfamily, expressed by monocytes, B cells, eosinophils, and at a higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. Structurally, Siglec-10 is most similar to the CD33-related group of Siglecs, and preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid. Studies have shown that Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), a glycoprotein expressed on endothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking, see for details. This interaction between Siglec-10 and VAP-1, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment. Studies have shown that clone 5G6 does not cross-react with Siglecs 3, 5, 7, 8 and 9, see for details.

Purification: Protein G purified

Immunogène: Recombinant human Siglec-10, fused with the Fc region of human IgG.

Type of Immunogen: Recombinant protein

Clone: 5G6

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: 4°C or -20°C, Avoid freeze-thaw cycles.

Détails sur SIGLEC10

Antigène: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Autre désignation: SIGLEC10 / SIGLEC-10 (SIGLEC10 Produits)

Synonymes: anticorps PRO940, anticorps SIGLEC-10, anticorps SLG2, anticorps Siglecg, anticorps SIGLEC10, anticorps slg2, anticorps pro940, anticorps siglec-10, anticorps sialic acid binding Ig like lectin 10, anticorps sialic acid binding Ig-like lectin 10, anticorps sialic acid-binding Ig-like lectin 10, anticorps SIGLEC10, anticorps Siglec10, anticorps LOC484343, anticorps LOC100066644, anticorps siglec10, anticorps LOC100513863, anticorps LOC100340374

Sujet: Name/Gene ID: SIGLEC10

Synonyms: SIGLEC10, SIGLEC-10, Siglec-like gene 2, Siglec-like protein 2, PRO940, SLG2

ID gène: 89790

UniProt: Q96LC7