C17orf53 anticorps (AA 282-527)

N° du produit ABIN1842990

Détail du produit anti-C17orf53 anticorps

Antigène: C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))

Épitope: AA 282-527

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C17orf53 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (fixed cells) (IF/ICC)

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human C17ORF53 (AA: 282-527) expressed in E. coli.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Détails sur C17orf53

Antigène: C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))

Autre désignation: C17ORF53 (C17ORF53 Produits)

Synonymes: anticorps chromosome 17 open reading frame 53, anticorps C17orf53

Sujet: C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17.Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes.Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1.Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death.Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome.Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth.Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Poids moléculaire: 69.8 kDa

ID gène: 78995

UniProt: Q8N3J3