BAT1 anticorps (C-Term)

N° du produit ABIN1881102

Détail du produit anti-BAT1 anticorps

Antigène: BAT1 (DDX39) (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 39 (DDX39))

Épitope: AA 351-380, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAT1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: M, Rat, B, C, D, Pig

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This BAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-380 amino acids from the C-terminal region of human BAT1.

Clone: RB22515

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-BAT1 (ABIN1881102)

Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: "Lysine acetylation targets protein complexes and co-regulates major cellular functions." dans: Science (New York, N.Y.), Vol. 325, Issue 5942, pp. 834-40, (2009) (PubMed).

Détails sur BAT1

Antigène: BAT1 (DDX39) (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 39 (DDX39))

Autre désignation: BAT1 (DDX39 Produits)

Synonymes: anticorps dxd39, anticorps MGC53693, anticorps MGC130793, anticorps ddx39, anticorps MGC53944, anticorps DDX39, anticorps 2610307C23Rik, anticorps BAT1, anticorps DDXL, anticorps Ddx39a, anticorps URH49, anticorps bat1, anticorps uap56, anticorps D6S81E, anticorps UAP56, anticorps Bat1, anticorps Bat1a, anticorps p47, anticorps DEAD-box helicase 39A S homeolog, anticorps nuclear RNA helicase, anticorps DExD-box helicase 39A, anticorps DEAD-box helicase 39A, anticorps ATP-dependent RNA helicase DDX39, anticorps ATP-dependent RNA helicase DDX39A, anticorps DEAD (Asp-Glu-Ala-Asp) box polypeptide 39b, anticorps DEAD (Asp-Glu-Ala-Asp) box polypeptide 39, anticorps DEAD-box helicase 39B L homeolog, anticorps DExD-box helicase 39B, anticorps ddx39a.S, anticorps ddx39, anticorps DDX39A, anticorps ddx39a, anticorps LOC100084960, anticorps ddx39b, anticorps Ddx39, anticorps ddx39b.L, anticorps DDX39B, anticorps Ddx39b

Sujet: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4. Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. It has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. It can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. It can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2 and THOC4.

Poids moléculaire: 48991

NCBI Accession: NP_004631, NP_542165

UniProt: Q13838

Pathways: Ribonucleoprotein Complex Subunit Organization