This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This BRSK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-384 amino acids from the Central region of human BRSK1.
Fogarty, Hardie: "C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest." dans: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 77-84, (2008) (PubMed).
Bright, Carling, Thornton: "Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation." dans: The Journal of biological chemistry, Vol. 283, Issue 22, pp. 14946-54, (2008) (PubMed).
Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to UV-or methyl methane sulfonate (MMS)-induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.