This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This CASQ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the Central region of human CASQ2.
CASQ2
Reactivité: Humain
ELISA
Hôte: Lapin
Polyclonal
HRP
Indications d'application
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Kirchhefer, Wehrmeister, Postma, Pohlentz, Mormann, Kucerova, Müller, Schmitz, Schulze-Bahr, Wilde, Neumann: "The human CASQ2 mutation K206N is associated with hyperglycosylation and altered cellular calcium handling." dans: Journal of molecular and cellular cardiology, Vol. 49, Issue 1, pp. 95-105, (2010) (PubMed).
Wei, Hanna, Beard, Dulhunty: "Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle." dans: Cell calcium, Vol. 45, Issue 5, pp. 474-84, (2009) (PubMed).
The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq].