This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This CCNB3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T280 of human CCNB3.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Cheng, Kapranov, Drenkow, Dike, Brubaker, Patel, Long, Stern, Tammana, Helt, Sementchenko, Piccolboni, Bekiranov, Bailey, Ganesh, Ghosh, Bell, Gerhard, Gingeras: "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution." dans: Science (New York, N.Y.), Vol. 308, Issue 5725, pp. 1149-54, (2005) (PubMed).
Mouland, Coady, Yao, Cohen: "Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression." dans: Virology, Vol. 292, Issue 2, pp. 321-30, (2002) (PubMed).
Nguyen, Manova, Capodieci, Lindon, Bottega, Wang, Refik-Rogers, Pines, Wolgemuth, Koff: "Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin." dans: The Journal of biological chemistry, Vol. 277, Issue 44, pp. 41960-9, (2002) (PubMed).
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chick and Drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and be required for proper spindle reorganization and restoration of the interphase nucleus. Two transcript variants encoding different isoforms have been found for this gene.