This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This CIB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-151 amino acids from the C-terminal region of human CIB1.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." dans: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).
Jarman, Moretti, Zebol, Pitson: "Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1." dans: The Journal of biological chemistry, Vol. 285, Issue 1, pp. 483-92, (2009) (PubMed).
Yamniuk, Anderson, Fraser, Vogel: "Auxiliary Ca2+ binding sites can influence the structure of CIB1." dans: Protein science : a publication of the Protein Society, Vol. 18, Issue 5, pp. 1128-34, (2009) (PubMed).
Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." dans: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).
Denofrio, Yuan, Temple, Gentry, Parise: "Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: potential compensation by CIB family members." dans: Thrombosis and haemostasis, Vol. 100, Issue 5, pp. 847-56, (2008) (PubMed).
Antigène
CIB1
(Calcium and Integrin-Binding Protein 1 (CIB1))
anticorps zgc:112015, anticorps CIB, anticorps CIBP, anticorps KIP1, anticorps PRKDCIP, anticorps SIP2-28, anticorps Cibkip, anticorps Kip, anticorps Prkdcip, anticorps Cib, anticorps Sip2-28, anticorps calcium and integrin binding 1 (calmyrin), anticorps calcium and integrin-binding protein 1, anticorps calcium and integrin binding 1, anticorps Calcium and integrin-binding protein 1, anticorps cib1, anticorps CpipJ_CPIJ003501, anticorps CIB1, anticorps kip1, anticorps Cib1
Sujet
The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined, however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3).