CRYAA anticorps (AA 77-106)

N° du produit ABIN1881229

Détail du produit anti-CRYAA anticorps

Antigène: CRYAA (Crystallin, alpha A (CRYAA))

Épitope: AA 77-106

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRYAA est non-conjugé

Application: Western Blotting (WB)

Homologie: B, Hs, M, Pig, Rb, Rat, Sh

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CRYAA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-106 amino acids from the Central region of human CRYAA.

Clone: RB28544

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CRYAA (ABIN1881229)

Deng, Chen, Xie, Zhao, Gong, Liu, Zhang, Sun, Liu, Ma, Batra, Li: "The small heat shock protein alphaA-crystallin is expressed in pancreas and acts as a negative regulator of carcinogenesis." dans: Biochimica et biophysica acta, Vol. 1802, Issue 7-8, pp. 621-31, (2010) (PubMed).

Li, Yang, Ma, Zhang, Zhang, Wang, Zhu: "Autosomal dominant congenital nuclear cataracts caused by a CRYAA gene mutation." dans: Current eye research, Vol. 35, Issue 6, pp. 492-8, (2010) (PubMed).

Pang, Su, Feng, Tang, Gu, Zhang, Ma, Yan: "Effects of congenital cataract mutation R116H on alphaA-crystallin structure, function and stability." dans: Biochimica et biophysica acta, Vol. 1804, Issue 4, pp. 948-56, (2010) (PubMed).

Bhagyalaxmi, Padma, Reddy, Reddy: "Association of G>A transition in exon-1 of alpha crystallin gene in age-related cataracts." dans: Oman journal of ophthalmology, Vol. 3, Issue 1, pp. 7-12, (2010) (PubMed).

Détails sur CRYAA

Antigène: CRYAA (Crystallin, alpha A (CRYAA))

Autre désignation: CRYAA (CRYAA Produits)

Synonymes: anticorps CRYA1, anticorps CTRCT9, anticorps HSPB4, anticorps AI323437, anticorps Acry-1, anticorps Crya-1, anticorps Crya1, anticorps DAcry-1, anticorps lop18, anticorps alpha-a-crystallin, anticorps cryaa-A, anticorps CRYAA, anticorps wu:fc06h04, anticorps zgc:92036, anticorps HspB4, anticorps crystallin alpha A, anticorps crystallin, alpha A, anticorps alphaA-crystallin, anticorps alpha-crystallin A chain-like, anticorps crystallin alpha A S homeolog, anticorps alpha-crystallin A chain, anticorps CRYAA, anticorps Cryaa, anticorps CpipJ_CPIJ005646, anticorps cryaa, anticorps LOC100384978, anticorps cryaa.S, anticorps LOC458589, anticorps LOC102724652

Sujet: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits, the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq].

Poids moléculaire: 19909

NCBI Accession: NP_000385

UniProt: P02489

Pathways: M Phase