This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This CSF2RA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-394 amino acids from the C-terminal region of human CSF2RA.
CSF2RA
Reactivité: Humain
WB
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Mirza, Walker, Chen, Murphy, Young: "The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation." dans: The Biochemical journal, Vol. 426, Issue 3, pp. 307-17, (2010) (PubMed).
Martinez-Moczygemba, Doan, Elidemir, Fan, Cheung, Lei, Moore, Tavana, Lewis, Zhu, Muzny, Gibbs, Huston: "Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1." dans: The Journal of experimental medicine, Vol. 205, Issue 12, pp. 2711-6, (2008) (PubMed).
Hansen, Hercus, McClure, Stomski, Dottore, Powell, Ramshaw, Woodcock, Xu, Guthridge, McKinstry, Lopez, Parker: "The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation." dans: Cell, Vol. 134, Issue 3, pp. 496-507, (2008) (PubMed).
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.