EIF3E anticorps (AA 248-276)

N° du produit ABIN1881290

Détail du produit anti-EIF3E anticorps

Antigène: EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))

Épitope: AA 248-276

Reactivité: Humain, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF3E est non-conjugé

Application: Western Blotting (WB)

Homologie: X, B, C, Pr, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This EIF3E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-276 amino acids from the Central region of human EIF3E.

Clone: RB40515

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-EIF3E (ABIN1881290)

Grzmil, Rzymski, Milani, Harris, Capper, Saunders, Salhan, Ragoussis, Norbury: "An oncogenic role of eIF3e/INT6 in human breast cancer." dans: Oncogene, Vol. 29, Issue 28, pp. 4080-9, (2010) (PubMed).

Zhou, Sandercock, Fraser, Ridlova, Stephens, Schenauer, Yokoi-Fong, Barsky, Leary, Hershey, Doudna, Robinson: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, (2008) (PubMed).

Morris, Wittmann, Jäck, Jalinot: "Human INT6/eIF3e is required for nonsense-mediated mRNA decay." dans: EMBO reports, Vol. 8, Issue 6, pp. 596-602, (2007) (PubMed).

Masutani, Sonenberg, Yokoyama, Imataka: "Reconstitution reveals the functional core of mammalian eIF3." dans: The EMBO journal, Vol. 26, Issue 14, pp. 3373-83, (2007) (PubMed).

Sirchia, Luparello: "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells." dans: Biological chemistry, Vol. 388, Issue 5, pp. 457-65, (2007) (PubMed).

Détails sur EIF3E

Antigène: EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))

Autre désignation: EIF3E (EIF3E Produits)

Synonymes: anticorps EIF3-P48, anticorps EIF3S6, anticorps INT6, anticorps eIF3-p46, anticorps 48kDa, anticorps Eif3s6, anticorps Int6, anticorps eIF3-p48, anticorps eif3-p48, anticorps eif3s6, anticorps eif3s6-A, anticorps eIF3e, anticorps eIF3-S6, anticorps eif3s6-B, anticorps EIF3SE, anticorps eif3s6b, anticorps im:7147439, anticorps QtsA-18056, anticorps eukaryotic translation initiation factor 3 subunit E, anticorps eukaryotic translation initiation factor 3, subunit E, anticorps eukaryotic translation initiation factor 3 subunit E L homeolog, anticorps eukaryotic translation initiation factor 3 subunit 6, anticorps eukaryotic translation initiation factor 3 subunit E S homeolog, anticorps eukaryotic translation initiation factor 3, subunit E, a, anticorps Eukaryotic translation initiation factor 3 subunit E, anticorps eukaryotic translation initiation factor 3, subunit E, b, anticorps EIF3E, anticorps Eif3e, anticorps eif3e, anticorps eif3e.L, anticorps LOC692936, anticorps eif3e.S, anticorps eif3ea, anticorps eif-3.E, anticorps eif3eb, anticorps LOC108348260, anticorps int6

Sujet: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD), may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.

Poids moléculaire: 52221

NCBI Accession: NP_001559

UniProt: P60228

Pathways: Ribonucleoprotein Complex Subunit Organization, Hepatitis C