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EIF3E anticorps (AA 248-276)

EIF3E Reactivité: Humain, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal RB40515 unconjugated
N° du produit ABIN1881290
  • Antigène Voir toutes EIF3E Anticorps
    EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))
    Épitope
    • 6
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 248-276
    Reactivité
    • 44
    • 23
    • 19
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain, Poisson zèbre (Danio rerio)
    Hôte
    • 42
    • 1
    • 1
    Lapin
    Clonalité
    • 43
    • 1
    Polyclonal
    Conjugué
    • 27
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp EIF3E est non-conjugé
    Application
    • 35
    • 19
    • 7
    • 7
    • 6
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    X, B, C, Pr, M, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This EIF3E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-276 amino acids from the Central region of human EIF3E.
    Clone
    RB40515
    Isotype
    Ig Fraction
    Top Product
    Discover our top product EIF3E Anticorps primaire
  • Indications d'application
    WB: 1:1000. WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Grzmil, Rzymski, Milani, Harris, Capper, Saunders, Salhan, Ragoussis, Norbury: "An oncogenic role of eIF3e/INT6 in human breast cancer." dans: Oncogene, Vol. 29, Issue 28, pp. 4080-9, (2010) (PubMed).

    Zhou, Sandercock, Fraser, Ridlova, Stephens, Schenauer, Yokoi-Fong, Barsky, Leary, Hershey, Doudna, Robinson: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, (2008) (PubMed).

    Morris, Wittmann, Jäck, Jalinot: "Human INT6/eIF3e is required for nonsense-mediated mRNA decay." dans: EMBO reports, Vol. 8, Issue 6, pp. 596-602, (2007) (PubMed).

    Masutani, Sonenberg, Yokoyama, Imataka: "Reconstitution reveals the functional core of mammalian eIF3." dans: The EMBO journal, Vol. 26, Issue 14, pp. 3373-83, (2007) (PubMed).

    Sirchia, Luparello: "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells." dans: Biological chemistry, Vol. 388, Issue 5, pp. 457-65, (2007) (PubMed).

  • Antigène
    EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))
    Autre désignation
    EIF3E (EIF3E Produits)
    Synonymes
    anticorps EIF3-P48, anticorps EIF3S6, anticorps INT6, anticorps eIF3-p46, anticorps 48kDa, anticorps Eif3s6, anticorps Int6, anticorps eIF3-p48, anticorps eif3-p48, anticorps eif3s6, anticorps eif3s6-A, anticorps eIF3e, anticorps eIF3-S6, anticorps eif3s6-B, anticorps EIF3SE, anticorps eif3s6b, anticorps im:7147439, anticorps QtsA-18056, anticorps eukaryotic translation initiation factor 3 subunit E, anticorps eukaryotic translation initiation factor 3, subunit E, anticorps eukaryotic translation initiation factor 3 subunit E L homeolog, anticorps eukaryotic translation initiation factor 3 subunit 6, anticorps eukaryotic translation initiation factor 3 subunit E S homeolog, anticorps eukaryotic translation initiation factor 3, subunit E, a, anticorps Eukaryotic translation initiation factor 3 subunit E, anticorps eukaryotic translation initiation factor 3, subunit E, b, anticorps EIF3E, anticorps Eif3e, anticorps eif3e, anticorps eif3e.L, anticorps LOC692936, anticorps eif3e.S, anticorps eif3ea, anticorps eif-3.E, anticorps eif3eb, anticorps LOC108348260, anticorps int6
    Sujet
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD), may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
    Poids moléculaire
    52221
    NCBI Accession
    NP_001559
    UniProt
    P60228
    Pathways
    Ribonucleoprotein Complex Subunit Organization, Hepatitis C
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