ERBB3 anticorps (pTyr1289)

N° du produit ABIN1881314

Détail du produit anti-ERBB3 anticorps

Antigène: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Épitope: pTyr1289

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERBB3 est non-conjugé

Application: Western Blotting (WB), Dot Blot (DB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ERBB3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1289 of human ERBB3.

Clone: RB25837

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-ERBB3 (ABIN1881314)

Huang, Gao, Wang, McManaman, Thor, Yang, Esteva, Liu: "Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin." dans: Cancer research, Vol. 70, Issue 3, pp. 1204-14, (2010) (PubMed).

Pierce, Ahsan: "Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk." dans: Human heredity, Vol. 69, Issue 3, pp. 193-201, (2010) (PubMed).

Carr, Niederer, Williams, Harper, Watts, Lyons, Smith: "Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis." dans: BMC medical genetics, Vol. 10, pp. 121, (2009) (PubMed).

Zhang, Opresko, Shankaran, Chrisler, Wiley, Resat: "HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells." dans: BMC cell biology, Vol. 10, pp. 78, (2009) (PubMed).

Li, Feng, He: "Case-control study of association between the functional candidate gene ERBB3 and schizophrenia in Caucasian population." dans: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, Vol. 10, Issue 4 Pt 2, pp. 595-8, (2009) (PubMed).

Détails sur ERBB3

Antigène: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Autre désignation: ERBB3 (ERBB3 Produits)

Synonymes: anticorps ErbB-3, anticorps HER3, anticorps LCCS2, anticorps MDA-BF-1, anticorps c-erbB-3, anticorps c-erbB3, anticorps erbB3-S, anticorps p180-ErbB3, anticorps p45-sErbB3, anticorps p85-sErbB3, anticorps ERBB3, anticorps C76256, anticorps Erbb-3, anticorps Erbb3r, anticorps Her3, anticorps nuc-ErbB3, anticorps erb-b2 receptor tyrosine kinase 3, anticorps v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), anticorps ERBB3, anticorps Erbb3

Sujet: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form.

Poids moléculaire: 148098

NCBI Accession: NP_001005915, NP_001973

UniProt: P21860

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway