FADD anticorps (AA 106-135)

N° du produit ABIN1881331

Détail du produit anti-FADD anticorps

Antigène: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Épitope: AA 106-135

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FADD est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This FADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the Central region of human FADD.

Clone: RB40884

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-FADD (ABIN1881331)

Papoff, Trivieri, Crielesi, Ruberti, Marsilio, Ruberti: "FADD-calmodulin interaction: a novel player in cell cycle regulation." dans: Biochimica et biophysica acta, Vol. 1803, Issue 8, pp. 898-911, (2010) (PubMed).

Li, Jayarama, Ganesh, Mordi, Carr, Kanteti, Hay, Prabhakar: "Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4." dans: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22713-22, (2010) (PubMed).

Ko, Yang, Chung, Wen, Hsu, Miaw, Hsia: "Lack of Fas-pathway gene mutations in primary resected esophageal squamous cell carcinoma." dans: Chang Gung medical journal, Vol. 33, Issue 2, pp. 145-51, (2010) (PubMed).

Hindryckx, De Vos, Jacques, Ferdinande, Peeters, Olievier, Bogaert, Brinkman, Vandenabeele, Elewaut, Laukens: "Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6306-16, (2010) (PubMed).

Silva, Blanton, Parrado, Melo, Morato, Reis, Dias, Castro, Vasconcelos, Goddard, Barreto, Reis, Teixeira: "Dengue hemorrhagic fever is associated with polymorphisms in JAK1." dans: European journal of human genetics : EJHG, Vol. 18, Issue 11, pp. 1221-7, (2010) (PubMed).

Détails sur FADD

Antigène: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Autre désignation: FADD (FADD Produits)

Synonymes: anticorps MORT1, anticorps Mort1/FADD, anticorps Mort1, anticorps TNFRSF6, anticorps adaptor, anticorps fadd, anticorps mort1, anticorps xfadd, anticorps Fas associated via death domain, anticorps Fas (TNFRSF6)-associated via death domain, anticorps Fas associated via death domain S homeolog, anticorps Fas (tnfrsf6)-associated via death domain, anticorps FADD, anticorps Fadd, anticorps fadd.S, anticorps fadd

Sujet: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Poids moléculaire: 23279

NCBI Accession: NP_003815

UniProt: Q13158

Pathways: Apoptose, Signalisation TLR, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades