FANCL anticorps (C-Term)

N° du produit ABIN1881336

Détail du produit anti-FANCL anticorps

Antigène: FANCL (Fanconi Anemia, Complementation Group L (FANCL))

Épitope: AA 274-302, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FANCL est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This FANCL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-302 amino acids from the C-terminal region of human FANCL.

Clone: RB23901

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-FANCL (ABIN1881336)

Zhang, Zhao, Park, Wang, Dyer, Liu, Klee, McNiven, Tindall, Molina, Fei: "FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth." dans: The Journal of clinical investigation, Vol. 120, Issue 5, pp. 1524-34, (2010) (PubMed).

García, Fernández, Osorio, Barroso, Fernández, Urioste, Benítez et al.: "Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer ..." dans: Carcinogenesis, Vol. 30, Issue 11, pp. 1898-902, (2009) (PubMed).

Longerich, San Filippo, Liu, Sung: "FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL." dans: The Journal of biological chemistry, Vol. 284, Issue 35, pp. 23182-6, (2009) (PubMed).

McWilliams, Bamlet, de Andrade, Rider, Couch, Cunningham, Matsumoto, Rabe, Hammer, Petersen: "Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk." dans: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 9, pp. 2549-52, (2009) (PubMed).

Hess, Ameziane, Schuurhuis, Errami, Denkers, Kaspers, Cloos, Joenje, Reinhardt, Ossenkoppele, Zwaan, Waisfisz: "Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia." dans: Cellular oncology : the official journal of the International Society for Cellular Oncology, Vol. 30, Issue 4, pp. 299-306, (2008) (PubMed).

Détails sur FANCL

Antigène: FANCL (Fanconi Anemia, Complementation Group L (FANCL))

Autre désignation: FANCL (FANCL Produits)

Synonymes: anticorps FAAP43, anticorps PHF9, anticorps POG, anticorps 2010322C19Rik, anticorps AW554273, anticorps B230118H11Rik, anticorps Phf9, anticorps Pog, anticorps gcd, anticorps Fanconi anemia complementation group L, anticorps Fanconi anemia, complementation group L, anticorps FANCL, anticorps Fancl

Sujet: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms.

Poids moléculaire: 42905

NCBI Accession: NP_001108108, NP_060532

UniProt: Q9NW38

Pathways: Réparation de l'ADN