FBXW5 anticorps (AA 324-350)

N° du produit ABIN1881341

Détail du produit anti-FBXW5 anticorps

Antigène: FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

Épitope: AA 324-350

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXW5 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This FBXW5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 324-350 amino acids from the Central region of human FBXW5.

Clone: RB40653

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-FBXW5 (ABIN1881341)

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." dans: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Minoda, Sakurai, Kobayashi, Yoshimura, Takaesu: "An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway." dans: Biochemical and biophysical research communications, Vol. 381, Issue 3, pp. 412-7, (2009) (PubMed).

Hu, Zacharek, He, Lee, Shumway, Duronio, Xiong: "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase." dans: Genes & development, Vol. 22, Issue 7, pp. 866-71, (2008) (PubMed).

Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: "DNA sequence and analysis of human chromosome 9. ..." dans: Nature, Vol. 429, Issue 6990, pp. 369-74, (2004) (PubMed).

Détails sur FBXW5

Antigène: FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

Autre désignation: FBXW5 (FBXW5 Produits)

Synonymes: anticorps Fbw5, anticorps AI159739, anticorps F-box and WD repeat domain containing 5, anticorps F-box and WD-40 domain protein 5, anticorps FBXW5, anticorps Fbxw5

Sujet: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.

Poids moléculaire: 63922

NCBI Accession: NP_061871

UniProt: Q969U6