GAB2 anticorps (N-Term)

N° du produit ABIN1881358

Détail du produit anti-GAB2 anticorps

Antigène: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Épitope: AA 3-30, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GAB2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Homologie: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This GAB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-30 amino acids from the N-terminal region of human GAB2.

Clone: RB21209

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-GAB2 (ABIN1881358)

Dunn, Cheung, Agarwalla, Thomas, Zektser, Karst, Boehm, Weir, Berlin, Zou, Getz, Liu, Hirsch, Vazquez, Root, Beroukhim, Drapkin, Hahn: "In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 3, pp. 1102-7, (2014) (PubMed).

Yamasaki, Nishida, Hibi, Sakuma, Shiina, Takeuchi, Ohnishi, Hirano, Saito: "Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules." dans: The Journal of biological chemistry, Vol. 276, Issue 48, pp. 45175-83, (2001) (PubMed).

Détails sur GAB2

Antigène: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Autre désignation: GAB2 (GAB2 Produits)

Synonymes: anticorps GAB2, anticorps AI463667, anticorps D130058I17Rik, anticorps p97, anticorps GRB2 associated binding protein 2, anticorps GRB2-associated binding protein 2, anticorps growth factor receptor bound protein 2-associated protein 2, anticorps GAB2, anticorps gab2, anticorps Gab2

Sujet: GAB2 is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor.

Poids moléculaire: 74458

NCBI Accession: NP_036428, NP_536739

UniProt: Q9UQC2

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, BCR Signaling, L'effet Warburg