This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This GEMIN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-301 amino acids from the N-terminal region of human GEMIN4.
GEMIN4
Reactivité: Humain
WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro), ICC
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Clague, Lippman, Yang, Hildebrandt, Ye, Lee, Wu: "Genetic variation in MicroRNA genes and risk of oral premalignant lesions." dans: Molecular carcinogenesis, Vol. 49, Issue 2, pp. 183-9, (2010) (PubMed).
Kim, Choi, Jin, Kang, Choi, Jeon, Lee, Kim, Kim, Kim, Son, Jung, Park: "Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study." dans: Molecular carcinogenesis, Vol. 49, Issue 10, pp. 913-21, (2010) (PubMed).
Wilker, Baccarelli, Suh, Vokonas, Wright, Schwartz: "Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes." dans: Environmental health perspectives, Vol. 118, Issue 7, pp. 943-8, (2010) (PubMed).
Ye, Wang, Gu, Yang, Lin, Ajani, Wu: "Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk." dans: Cancer prevention research (Philadelphia, Pa.), Vol. 1, Issue 6, pp. 460-9, (2009) (PubMed).
Antigène
GEMIN4
(Gem (Nuclear Organelle) Associated Protein 4 (GEMIN4))
The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.