Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This GSTT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-141 amino acids from the Central region of human GSTT2.
GSTT2
Reactivité: Humain
WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro)
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:1000. IHC-P: 1:100. IHC-P: 1:100
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Canova, Richiardi, Merletti, Pentenero, Gervasio, Tanturri, Garzino-Demo, Pecorari, Talamini, Barzan, Sulfaro, Franchini, Muzzolini, Bordin, Pugliese, Macrì, Simonato: "Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern Italy." dans: Tumori, Vol. 96, Issue 1, pp. 1-10, (2010) (PubMed).
Wang, Chanock, Tang, Li, Edwards, Jedrychowski, Perera: "Effect of gene-environment Interactions on mental development in African American, Dominican, and Caucasian mothers and newborns." dans: Annals of human genetics, Vol. 74, Issue 1, pp. 46-56, (2010) (PubMed).
Moyer, Sun, Batzler, Li, Schaid, Yang, Weinshilboum: "Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy." dans: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 3, pp. 811-21, (2010) (PubMed).
Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55 % amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.