This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This HBE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the Central region of human HBE1.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Wang, Wang, Ma, Nie, Ju, Liu, Deng, Yao, Gui, Li, Guo, Ma, Tan, Zhao: "Heterochromatin Protein 1γ Is a Novel Epigenetic Repressor of Human Embryonic ϵ-Globin Gene Expression." dans: The Journal of biological chemistry, Vol. 292, Issue 12, pp. 4811-4817, (2017) (PubMed).
Tachavanich, Viprakasit, Chinchang, Glomglao, Pung-Amritt, Tanphaichitr: "Clinical and hematological phenotype of homozygous hemoglobin E: revisit of a benign condition with hidden reproductive risk." dans: The Southeast Asian journal of tropical medicine and public health, Vol. 40, Issue 2, pp. 306-16, (2009) (PubMed).
Das, Sengupta: "HbE genotypes and fertility: a study on a Tibeto-Burmese population in Upper Assam, India." dans: Annals of human biology, Vol. 35, Issue 4, pp. 422-31, (2008) (PubMed).
The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I, two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3'