LIN7B anticorps (N-Term)

N° du produit ABIN1881500

Détail du produit anti-LIN7B anticorps

Antigène: LIN7B (Lin-7 Homolog B (LIN7B))

Épitope: AA 35-62, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LIN7B est non-conjugé

Application: Western Blotting (WB)

Homologie: B, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This LIN7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human LIN7B.

Clone: RB40557

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-LIN7B (ABIN1881500)

Zucker, Kama, Kuhn, Thu, Orlando, Dunah, Gokce, Taylor, Lambeck, Friedrich, Lindenberg, Faull, Weiller, Young, Luthi-Carter: "Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease." dans: Journal of neuropathology and experimental neurology, Vol. 69, Issue 9, pp. 880-95, (2010) (PubMed).

Sudo, Ito, Iwamoto, Morishita, Asano, Nagata: "Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons." dans: Neuroscience research, Vol. 56, Issue 4, pp. 347-55, (2006) (PubMed).

Li, Benard, Margolskee: "Ggamma13 interacts with PDZ domain-containing proteins." dans: The Journal of biological chemistry, Vol. 281, Issue 16, pp. 11066-73, (2006) (PubMed).

Kawai, Fukuda, Mukai, Murata: "MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase." dans: The Journal of biological chemistry, Vol. 280, Issue 47, pp. 39200-7, (2005) (PubMed).

Détails sur LIN7B

Antigène: LIN7B (Lin-7 Homolog B (LIN7B))

Autre désignation: LIN7B (LIN7B Produits)

Synonymes: anticorps LIN7B, anticorps LIN-7B, anticorps MALS-2, anticorps MALS2, anticorps VELI2, anticorps Veli2, anticorps Veli1a, anticorps lin-7 homolog B, crumbs cell polarity complex component, anticorps lin-7 homolog B (C. elegans), anticorps LIN7B, anticorps Lin7b

Sujet: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).

Poids moléculaire: 22896

NCBI Accession: NP_071448

UniProt: Q9HAP6

Pathways: Synaptic Membrane