GPR68 anticorps (AA 200-225)

N° du produit ABIN1881516

Détail du produit anti-GPR68 anticorps

Antigène: GPR68 (G Protein-Coupled Receptor 68 (GPR68))

Épitope: AA 200-225

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPR68 est non-conjugé

Application: Western Blotting (WB)

Homologie: B, H

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Gpr68 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-225 amino acids from the Central region of mouse Gpr68.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-GPR68 (ABIN1881516)

Frick, Krieger, Nehrke, Bushinsky: "Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1." dans: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 24, Issue 2, pp. 305-13, (2009) (PubMed).

Singh, Berk, Oates, Zhao, Tan, Jiang, Zhou, Kirmani, Steinmetz, Lindner, Xu: "Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer." dans: Journal of the National Cancer Institute, Vol. 99, Issue 17, pp. 1313-27, (2007) (PubMed).

Détails sur GPR68

Antigène: GPR68 (G Protein-Coupled Receptor 68 (GPR68))

Autre désignation: Gpr68 (GPR68 Produits)

Synonymes: anticorps GPR68, anticorps GPR12A, anticorps OGR1, anticorps BB131428, anticorps Ogr1, anticorps G protein-coupled receptor 68, anticorps GPR68, anticorps LOC100348269, anticorps Gpr68

Sujet: Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer.

Poids moléculaire: 41209

NCBI Accession: NP_001171144, NP_001171145, NP_780702

UniProt: Q8BFQ3