Neuregulin 3 anticorps (AA 688-717)

N° du produit ABIN1881587

Détail du produit anti-Neuregulin 3 anticorps

Antigène: Neuregulin 3 (NRG3)

Épitope: AA 688-717

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neuregulin 3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This NRG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 688-717 amino acids of human NRG3.

Clone: RB2201

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-Neuregulin 3 (ABIN1881587)

Wansbury, Panchal, James, Parry, Ashworth, Howard: "Dynamic expression of Erbb pathway members during early mammary gland morphogenesis." dans: The Journal of investigative dermatology, Vol. 128, Issue 4, pp. 1009-21, (2008) (PubMed).

Zhang, Sliwkowski, Mark, Frantz, Akita, Sun, Hillan, Crowley, Brush, Godowski: "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 18, pp. 9562-7, (1997) (PubMed).

Détails sur Neuregulin 3

Antigène: Neuregulin 3 (NRG3)

Autre désignation: NRG3 (NRG3 Produits)

Synonymes: anticorps NRG3, anticorps HRG3, anticorps pro-NRG3, anticorps ska, anticorps RGD1559678, anticorps neuregulin 3, anticorps pro-neuregulin-3, membrane-bound isoform, anticorps NRG3, anticorps nrg3, anticorps LOC100478170, anticorps Nrg3

Sujet: NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.

Poids moléculaire: 77901

NCBI Accession: NP_001010848, NP_001159445

UniProt: P56975

Pathways: Signalisation RTK