This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This PRLR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-179 amino acids from the Central region of human PRLR.
PRLR
Reactivité: Humain
IHC, ELISA
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Kline, Rycyzyn, Clevenger: "Characterization of a novel and functional human prolactin receptor isoform (deltaS1PRLr) containing only one extracellular fibronectin-like domain." dans: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 10, pp. 2310-22, (2002) (PubMed).
Hu, Meng, Dufau: "Isolation and characterization of two novel forms of the human prolactin receptor generated by alternative splicing of a newly identified exon 11." dans: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 41086-94, (2001) (PubMed).
Kline, Roehrs, Clevenger: "Functional characterization of the intermediate isoform of the human prolactin receptor." dans: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35461-8, (2000) (PubMed).
Hu, Zhuang, Meng, Leondires, Dufau: "The human prolactin receptor gene structure and alternative promoter utilization: the generic promoter hPIII and a novel human promoter hP(N)." dans: The Journal of clinical endocrinology and metabolism, Vol. 84, Issue 3, pp. 1153-6, (1999) (PubMed).
Boutin, Edery, Shirota, Jolicoeur, Lesueur, Ali, Gould, Djiane, Kelly: "Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cells." dans: Molecular endocrinology (Baltimore, Md.), Vol. 3, Issue 9, pp. 1455-61, (1990) (PubMed).
This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.