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PROX1 anticorps (AA 175-206)

PROX1 Reactivité: Humain WB Hôte: Lapin Polyclonal RB15516 unconjugated
N° du produit ABIN1881686
  • Antigène Voir toutes PROX1 Anticorps
    PROX1 (Prospero Homeobox 1 (PROX1))
    Épitope
    • 16
    • 14
    • 9
    • 9
    • 8
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 175-206
    Reactivité
    • 99
    • 53
    • 26
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 91
    • 8
    Lapin
    Clonalité
    • 90
    • 9
    Polyclonal
    Conjugué
    • 47
    • 9
    • 8
    • 7
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PROX1 est non-conjugé
    Application
    • 81
    • 47
    • 36
    • 28
    • 13
    • 13
    • 12
    • 4
    • 2
    • 2
    Western Blotting (WB)
    Homologie
    M
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This PROX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-206 amino acids from human PROX1.
    Clone
    RB15516
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PROX1 Anticorps primaire
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Nagai, Li, Hatano, Toshihito, Yuge, Ito, Utsumi, Saito, Kinoshita: "Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies." dans: Genes, chromosomes & cancer, Vol. 38, Issue 1, pp. 13-21, (2003) (PubMed).

    Hong, Harvey, Noh, Schacht, Hirakawa, Detmar, Oliver: "Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate." dans: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 225, Issue 3, pp. 351-7, (2002) (PubMed).

    Petrova, Mäkinen, Mäkelä, Saarela, Virtanen, Ferrell, Finegold, Kerjaschki, Ylä-Herttuala, Alitalo: "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor." dans: The EMBO journal, Vol. 21, Issue 17, pp. 4593-9, (2002) (PubMed).

    Mouta Carreira, Nasser, di Tomaso, Padera, Boucher, Tomarev, Jain: "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis." dans: Cancer research, Vol. 61, Issue 22, pp. 8079-84, (2001) (PubMed).

  • Antigène
    PROX1 (Prospero Homeobox 1 (PROX1))
    Autre désignation
    PROX1 (PROX1 Produits)
    Synonymes
    anticorps xprox1, anticorps prospero, anticorps PROX1, anticorps LOC100232600, anticorps A230003G05Rik, anticorps prox1, anticorps zgc:111888, anticorps prospero homeobox 1, anticorps prospero homeobox 1 L homeolog, anticorps prospero homeobox 1a, anticorps PROX1, anticorps prox1.L, anticorps prox1, anticorps Prox1, anticorps prox1a
    Sujet
    The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens. Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system. Prox1 appears to be a specific and required regulator of the development of the lymphatic system. Prox1 also has been documented to be required for hepatocyte migration in the mouse. Loss of Prox1 results in a smaller liver with a reduced population of clustered hepatocytes. The homeodomain protein Prox1 regulates the egress of progenitor cells from the cell cycle in the embryonic mouse retina. Cells lacking Prox1 are less likely to stop dividing, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle. Prox1 acts as a key participant in progenitor-cell proliferation and cell-fate determination in the vertebrate retina.
    Poids moléculaire
    83203
    NCBI Accession
    NP_001257545, NP_002754
    UniProt
    Q92786
    Pathways
    Stem Cell Maintenance, Regulation of Muscle Cell Differentiation
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