This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This PTRH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human PTRH2.
PTRH2
Reactivité: Humain, Souris, Rat
WB, ELISA, IHC, IF
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Fan, Jiang, Suo, Liu, Xu, Ji, Zhang, Yang: "Down-regulation of the apoptosis-inducing factor or Bcl-2 inhibitor of transcription by RNA interference can alleviate TAp63gamma-induced apoptosis in esophageal squamous carcinoma EC9706 cells." dans: International journal of oncology, Vol. 35, Issue 2, pp. 359-67, (2009) (PubMed).
Biliran, Jan, Chen, Pasquale, Ruoslahti: "Protein kinase D is a positive regulator of Bit1 apoptotic function." dans: The Journal of biological chemistry, Vol. 283, Issue 42, pp. 28029-37, (2008) (PubMed).
Bouchentouf, Benabdallah, Rousseau, Schwartz, Tremblay: "Induction of Anoikis following myoblast transplantation into SCID mouse muscles requires the Bit1 and FADD pathways." dans: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 7, Issue 6, pp. 1491-505, (2007) (PubMed).
De Pereda, Waas, Jan, Ruoslahti, Schimmel, Pascual: "Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity." dans: The Journal of biological chemistry, Vol. 279, Issue 9, pp. 8111-5, (2004) (PubMed).
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity). Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.