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Retinoblastoma 1 anticorps (AA 586-615)

RB1 Reactivité: Humain WB, IF, IHC (p) Hôte: Lapin Polyclonal RB7977 unconjugated
N° du produit ABIN1881730
  • Antigène Voir toutes Retinoblastoma 1 (RB1) Anticorps
    Retinoblastoma 1 (RB1)
    Épitope
    • 35
    • 26
    • 25
    • 23
    • 21
    • 21
    • 18
    • 15
    • 11
    • 11
    • 10
    • 6
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 586-615
    Reactivité
    • 287
    • 120
    • 105
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 252
    • 37
    Lapin
    Clonalité
    • 247
    • 42
    Polyclonal
    Conjugué
    • 131
    • 17
    • 16
    • 16
    • 11
    • 10
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Retinoblastoma 1 est non-conjugé
    Application
    • 207
    • 117
    • 107
    • 80
    • 79
    • 37
    • 30
    • 28
    • 28
    • 21
    • 15
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This RB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-615 amino acids from human RB1.
    Clone
    RB7977
    Isotype
    Ig Fraction
    Top Product
    Discover our top product RB1 Anticorps primaire
  • Indications d'application
    IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Dasgupta, Sun, Wang, Fusaro, Betts, Padmanabhan, Sebti, Chellappan: "Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis." dans: Molecular and cellular biology, Vol. 24, Issue 21, pp. 9527-41, (2004) (PubMed).

    Cui, Shirai, Wakai, Yokoyama, Hirano, Hatakeyama: "Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma." dans: Human pathology, Vol. 35, Issue 10, pp. 1189-95, (2004) (PubMed).

    Borah, Verma, Robertson: "ORF73 of herpesvirus saimiri, a viral homolog of Kaposi's sarcoma-associated herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb." dans: Journal of virology, Vol. 78, Issue 19, pp. 10336-47, (2004) (PubMed).

    Dasgupta, Betts, Rastogi, Joshi, Morris, Brennan, Ordonez-Ercan, Chellappan: "Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery." dans: The Journal of biological chemistry, Vol. 279, Issue 37, pp. 38762-9, (2004) (PubMed).

  • Antigène
    Retinoblastoma 1 (RB1)
    Autre désignation
    RB1 (RB1 Produits)
    Synonymes
    anticorps OSRC, anticorps RB, anticorps p105-Rb, anticorps pRb, anticorps pp110, anticorps Rb, anticorps Rb-1, anticorps P105-RB, anticorps PP110, anticorps RB11, anticorps zgc:154147, anticorps RB transcriptional corepressor 1, anticorps RB transcriptional corepressor like 1, anticorps retinoblastoma 1, anticorps RB1, anticorps RBL1, anticorps Rb1, anticorps rb1
    Sujet
    The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in many types of cancer.[1] One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins.[2][3] Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer. Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral.
    Poids moléculaire
    106159
    NCBI Accession
    NP_000312
    UniProt
    P06400
    Pathways
    Cycle Cellulaire, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy
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