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SGOL2 anticorps (AA 391-419)

SGOL2 Reactivité: Humain WB Hôte: Lapin Polyclonal RB42663 unconjugated
N° du produit ABIN1881800
  • Antigène Voir toutes SGOL2 Anticorps
    SGOL2 (Shugoshin-Like 2 (SGOL2))
    Épitope
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 391-419
    Reactivité
    • 12
    • 1
    Humain
    Hôte
    • 12
    Lapin
    Clonalité
    • 12
    Polyclonal
    Conjugué
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SGOL2 est non-conjugé
    Application
    • 9
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.
    Clone
    RB42663
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Tanno, Kitajima, Honda, Ando, Ishiguro, Watanabe: "Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres." dans: Genes & development, Vol. 24, Issue 19, pp. 2169-79, (2010) (PubMed).

    Ross, Katzov-Eckert, Dubé, Brooks, Rassekh, Barhdadi, Feroz-Zada, Visscher, Brown, Rieder, Rogers, Phillips, Carleton, Hayden: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." dans: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, (2009) (PubMed).

    Lee, Kitajima, Tanno, Yoshida, Morita, Miyano, Miyake, Watanabe: "Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells." dans: Nature cell biology, Vol. 10, Issue 1, pp. 42-52, (2008) (PubMed).

    Huang, Feng, Famulski, Rattner, Liu, Kao, Muschel, Chan, Yen: "Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments." dans: The Journal of cell biology, Vol. 177, Issue 3, pp. 413-24, (2007) (PubMed).

    Kitajima, Sakuno, Ishiguro, Iemura, Natsume, Kawashima, Watanabe: "Shugoshin collaborates with protein phosphatase 2A to protect cohesin." dans: Nature, Vol. 441, Issue 7089, pp. 46-52, (2006) (PubMed).

  • Antigène
    SGOL2 (Shugoshin-Like 2 (SGOL2))
    Autre désignation
    SGOL2 (SGOL2 Produits)
    Synonymes
    anticorps SGO2, anticorps TRIPIN, anticorps 1110007N04Rik, anticorps 4932411A20Rik, anticorps 5730576N04Rik, anticorps AU018846, anticorps AV008062, anticorps D1Ertd8e, anticorps Tripin, anticorps shugoshin 2, anticorps shugoshin 2A, anticorps SGO2, anticorps Sgo2a
    Sujet
    Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.
    Poids moléculaire
    144739
    NCBI Accession
    NP_001153518, NP_689737
    UniProt
    Q562F6
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