This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This TES antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from the N-terminal region of human TES.
TES
Reactivité: Humain, Rat, Souris
WB, ELISA
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Qiu, Zhu, Yuan, Yan, Yang, Kong: "Frequent hypermethylation and loss of heterozygosity of the testis derived transcript gene in ovarian cancer." dans: Cancer science, Vol. 101, Issue 5, pp. 1255-60, (2010) (PubMed).
Gunduz, Gunduz, Beder, Nagatsuka, Fukushima, Sutcu, Delibas, Yamanaka, Shimizu, Nagai: "Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma." dans: Archives of otolaryngology--head & neck surgery, Vol. 135, Issue 3, pp. 254-60, (2009) (PubMed).
Boëda, Briggs, Higgins, Garvalov, Fadden, McDonald, Way: "Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding." dans: Molecular cell, Vol. 28, Issue 6, pp. 1071-82, (2007) (PubMed).
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. Multiple protein isoforms are encoded by transcript variants of this gene.