Tuberin anticorps (pThr1373)

N° du produit ABIN1881935

Détail du produit anti-Tuberin anticorps

Antigène: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Épitope: pThr1373

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tuberin est non-conjugé

Application: Dot Blot (DB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This rat TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T1373 of rat TSC2.

Clone: RB41276

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-Tuberin (ABIN1881935)

Larson, Liu, Stevens, Li, Li, Evers, Gao: "Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1." dans: The Journal of biological chemistry, Vol. 285, Issue 32, pp. 24987-98, (2010) (PubMed).

Di Nardo, Kramvis, Cho, Sadowski, Meikle, Kwiatkowski, Sahin: "Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 18, pp. 5926-37, (2009) (PubMed).

Shiono, Kobayashi, Takahashi, Sun, Abe, Zhang, Wang, Piao, Takagi, Mineki, Taka, Tada, Sonobe, Momose, Ueda, Hino: "The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition." dans: Oncogene, Vol. 27, Issue 52, pp. 6690-7, (2008) (PubMed).

Détails sur Tuberin

Antigène: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Autre désignation: TSC2 (TSC2 Produits)

Synonymes: anticorps TSC2, anticorps fc16b02, anticorps tuberin, anticorps wu:fc16b02, anticorps LAM, anticorps TSC4, anticorps Nafld, anticorps Tcs2, anticorps Rc, anticorps TSC complex subunit 2, anticorps tuberin, anticorps hypothetical protein, anticorps tuberous sclerosis 2, anticorps TSC2, anticorps LOC5569538, anticorps tsc2, anticorps PGTG_00159, anticorps Tsc2

Sujet: Acts as a tumor suppressor, may play a role in cell cycle regulation, acute phase response, and negative regulation of cell proliferation [RGD].

Poids moléculaire: 201278

NCBI Accession: NP_036812

UniProt: P49816

Pathways: Signalisation RTK, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus