This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This WBSCR22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-281 amino acids from the C-terminal region of human WBSCR22.
Merla, Ucla, Guipponi, Reymond: "Identification of additional transcripts in the Williams-Beuren syndrome critical region." dans: Human genetics, Vol. 110, Issue 5, pp. 429-38, (2002) (PubMed).
Stanchi, Bertocco, Toppo, Dioguardi, Simionati, Cannata, Zimbello, Lanfranchi, Valle: "Characterization of 16 novel human genes showing high similarity to yeast sequences." dans: Yeast (Chichester, England), Vol. 18, Issue 1, pp. 69-80, (2001) (PubMed).
Antigène
WBSCR22
(Williams Beuren Syndrome Chromosome Region 22 (WBSCR22))
This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23.