BBS4 anticorps (AA 1-240)

N° du produit ABIN1882046

Détail du produit anti-BBS4 anticorps

Antigène: BBS4 (Bardet-Biedl Syndrome 4 (BBS4))

Épitope: AA 1-240

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BBS4 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This BBS4 antibody is generated from a mice immunized with a recombinant protein between 1-240 amino acids from human BBS4.

Clone: 1292CT845-130-218

Isotype: IgG1

Information d'application

Indications d'application: IHC: 1:250. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-BBS4 (ABIN1882046)

Badano, Leitch, Ansley, May-Simera, Lawson, Lewis, Beales, Dietz, Fisher, Katsanis: "Dissection of epistasis in oligogenic Bardet-Biedl syndrome." dans: Nature, Vol. 439, Issue 7074, pp. 326-30, (2006) (PubMed).

Détails sur BBS4

Antigène: BBS4 (Bardet-Biedl Syndrome 4 (BBS4))

Autre désignation: BBS4 (BBS4 Produits)

Synonymes: anticorps CG13232, anticorps Dmel\\CG13232, anticorps zgc:152964, anticorps AW537059, anticorps AW742241, anticorps D9Ertd464e, anticorps Bardet-Biedl syndrome 4, anticorps bardet-biedl syndrome 4, anticorps Bardet-Biedl syndrome 4 (human), anticorps BBS4, anticorps bbs4, anticorps Bbs4

Sujet: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome.

Poids moléculaire: 58282

UniProt: Q96RK4

Pathways: Signalisation Hedgehog, Tube Formation, Maintenance of Protein Location