Topoisomerase I anticorps (N-Term)

N° du produit ABIN1882055

Détail du produit anti-Topoisomerase I anticorps

Antigène: Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))

Épitope: N-Term

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Topoisomerase I est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This TOP1 antibody is generated from a mouse immunized with a recombinant protein from the N-terminal region of human TOP1.

Clone: 1291CT875-142-166

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 1:1000. FC: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-Topoisomerase I (ABIN1882055)

Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." dans: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

Kunze, Yang, Dölberg, Sundarp, Knippers, Richter: "Structure of the human type I DNA topoisomerase gene." dans: The Journal of biological chemistry, Vol. 266, Issue 15, pp. 9610-6, (1991) (PubMed).

Détails sur Topoisomerase I

Antigène: Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))

Autre désignation: TOP1 (TOP1 Produits)

Synonymes: anticorps CG6146, anticorps Dmel\\CG6146, anticorps TOP1, anticorps TopI, anticorps Topo I, anticorps TopoI, anticorps dTopoI, anticorps l(1)G0134, anticorps l(1)G0201, anticorps l(1)G0229, anticorps l(1)G0278, anticorps l(1)top1, anticorps top1, anticorps topo I, anticorps topoI, anticorps DNA topoisomerase 1 beta, anticorps DNA topoisomerase I alpha, anticorps MGO1, anticorps MGOUN 1, anticorps MTE17.1, anticorps MTE17_1, anticorps TOP1BETA, anticorps TOPOISOMERASE 1, anticorps TOPI, anticorps AI467334, anticorps D130064I21Rik, anticorps Top-1, anticorps Ab2-086, anticorps topi, anticorps Topoisomerase 1, anticorps DNA topoisomerase I, anticorps DNA topoisomerase I alpha, anticorps DNA topoisomerase 1, anticorps topoisomerase (DNA) I, anticorps DNA topoisomerase I, gene 1 L homeolog, anticorps Top1, anticorps top1, anticorps topA, anticorps ZMO1193, anticorps MRAD2831_RS63095, anticorps Lferr_0016, anticorps PC1_2015, anticorps Za10_0136, anticorps Gbro_0575, anticorps Dd586_2108, anticorps Kvar_3044, anticorps Alvin_2069, anticorps Dacet_0849, anticorps Mrub_1615, anticorps Arnit_2962, anticorps Ndas_4953, anticorps Trad_2377, anticorps Acear_1653, anticorps Mahau_0844, anticorps Mesop_4109, anticorps Thein_1586, anticorps Theth_0241, anticorps TOP1ALPHA, anticorps top-1, anticorps TOP1, anticorps top1.1.L

Classe de substances: Viral Protein

Sujet: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Poids moléculaire: 90726

UniProt: P11387

Pathways: Caspase Cascade in Apoptosis, Stem Cell Maintenance