CSE1L anticorps (N-Term)

N° du produit ABIN1882070

Détail du produit anti-CSE1L anticorps

Antigène: CSE1L (Chromosome Segregation 1-Like (CSE1L))

Épitope: AA 55-84, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSE1L est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, Zf

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This Cellular Apoptosis Susceptibility antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-84 amino acids from the N-terminal region of human Cellular Apoptosis Susceptibility.

Clone: RB9332

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:100. WB: 1:1000. WB: 1:1000. IHC-P: 1:100. IHC-P: 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CSE1L (ABIN1882070)

Stella Tsai, Chen, Tung, Tsou, Tsao, Liao, Chen, Yeh, Yeh, Jiang: "Serum cellular apoptosis susceptibility protein is a potential prognostic marker for metastatic colorectal cancer." dans: The American journal of pathology, Vol. 176, Issue 4, pp. 1619-28, (2010) (PubMed).

Uen, Tai, Shen, Lee, Tsao, Deng, Chiou, Hsu, Hsieh, Liao, Jiang: "Differential distributions of CSE1L/CAS and E-cadherin in the polarized and non-polarized epithelial glands of neoplastic colorectal epithelium." dans: Journal of molecular histology, Vol. 41, Issue 4-5, pp. 259-66, (2010) (PubMed).

Tung, Tsai, Tung, Tsao, Chen, Yeh, Liao, Jiang: "Higher prevalence of secretory CSE1L/CAS in sera of patients with metastatic cancer." dans: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1570-7, (2009) (PubMed).

Goldberg, Alexander, Pellicena, Zhang, Tsuda, Miller: "Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells." dans: The Journal of biological chemistry, Vol. 278, Issue 47, pp. 46533-40, (2003) (PubMed).

Behrens, Brinkmann, Wellmann: "CSE1L/CAS: its role in proliferation and apoptosis." dans: Apoptosis : an international journal on programmed cell death, Vol. 8, Issue 1, pp. 39-44, (2003) (PubMed).

Jiang, Liao, Tai: "CAS/CSE 1 stimulates E-cadhrin-dependent cell polarity in HT-29 human colon epithelial cells." dans: Biochemical and biophysical research communications, Vol. 294, Issue 4, pp. 900-5, (2002) (PubMed).

Wellmann, Flemming, Behrens, Wuppermann, Lang, Oldhafer, Pastan, Brinkmann: "High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression." dans: International journal of molecular medicine, Vol. 7, Issue 5, pp. 489-94, (2001) (PubMed).

Brinkmann, Brinkmann, Bera, Wellmann, Pastan: "Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene." dans: Genomics, Vol. 58, Issue 1, pp. 41-9, (1999) (PubMed).

Détails sur CSE1L

Antigène: CSE1L (Chromosome Segregation 1-Like (CSE1L))

Autre désignation: Cellular Apoptosis Susceptibility (CSE1L Produits)

Synonymes: anticorps 2610100P18Rik, anticorps AA407533, anticorps Capts, anticorps Cas, anticorps Xpo2, anticorps cas, anticorps chromosome segregation 1-like (S. cerevisiae), anticorps CSE1 chromosome segregation 1-like (yeast), anticorps Cse1l, anticorps cse1l

Sujet: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, CSE1L may play a role both in apoptosis and in cell proliferation.

Poids moléculaire: 110417

NCBI Accession: NP_001243064, NP_001307

UniProt: P55060