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FKBP1A anticorps (C-Term)

FKBP1A Reactivité: Humain WB, FACS, IHC (p) Hôte: Lapin Polyclonal RB19307 unconjugated
N° du produit ABIN1882082
  • Antigène Voir toutes FKBP1A Anticorps
    FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))
    Épitope
    • 10
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 55-83, C-Term
    Reactivité
    • 57
    • 29
    • 21
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 55
    • 9
    Lapin
    Clonalité
    • 48
    • 16
    Polyclonal
    Conjugué
    • 28
    • 9
    • 8
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Cet anticorp FKBP1A est non-conjugé
    Application
    • 34
    • 23
    • 18
    • 8
    • 7
    • 7
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    B, Rb
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This FKBP1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the C-terminal region of human FKBP1A.
    Clone
    RB19307
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Gerard, Debyser, Desender, Baert, Brandt, Baekelandt, Engelborghs: "FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T." dans: Journal of neurochemistry, Vol. 106, Issue 1, pp. 121-33, (2008) (PubMed).

    Shor, Zhang, Toral-Barza, Lucas, Abraham, Gibbons, Yu: "A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis." dans: Cancer research, Vol. 68, Issue 8, pp. 2934-43, (2008) (PubMed).

  • Antigène
    FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))
    Autre désignation
    FKBP1A (FKBP1A Produits)
    Synonymes
    anticorps 12kDa, anticorps FKBP12, anticorps FKBP12-T1, anticorps FKBP12-T2, anticorps Fkbp, anticorps Fkbp1, anticorps mFKBP1, anticorps mFKBP12, anticorps FKBP-12, anticorps FKBP-1A, anticorps FKBP1, anticorps Rotamase, anticorps Fkbp12, anticorps ARABIDOPSIS THALIANA FK506-BINDING PROTEIN 12, anticorps ATFKBP12, anticorps FK506-binding protein 12, anticorps IMMUNOPHILIN, anticorps MSJ1.19, anticorps MSJ1_19, anticorps PKC12, anticorps PKCI2, anticorps PPIASE, anticorps FKBP1B, anticorps Fkbp2, anticorps fj02g10, anticorps zgc:73373, anticorps wu:fj02g10, anticorps FKBP1A, anticorps Bmfkbp13, anticorps zgc:103752, anticorps FK506 binding protein 1a, anticorps FK506 binding protein 1A, anticorps FK506-binding protein, anticorps FK506-binding protein 12, anticorps FK506 binding protein 1Aa, anticorps FK506 binding protein 1C, anticorps FK506-binding protein 59, anticorps FK506 binding protein like, anticorps FK506 binding protein 1A L homeolog, anticorps FK506 binding protein 1Ab, anticorps Fkbp1a, anticorps FKBP1A, anticorps Fkbp12, anticorps FKBP12, anticorps fkbp1aa, anticorps FKBP1C, anticorps EHI_180160, anticorps LOC5573443, anticorps Fkbp13, anticorps FKBPL, anticorps fkbp1a.L, anticorps fkbp1ab
    Sujet
    FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
    Poids moléculaire
    11951
    NCBI Accession
    NP_000792, NP_463460
    UniProt
    P62942
    Pathways
    Negative Regulation of Transporter Activity, Methionine Biosynthetic Process
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