FNTA anticorps (C-Term)

N° du produit ABIN1882083

Détail du produit anti-FNTA anticorps

Antigène: FNTA (Farnesyltransferase, CAAX Box, alpha (FNTA))

Épitope: AA 330-360, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FNTA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This FNTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-360 amino acids from the C-terminal region of human FNTA.

Clone: RB4794

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-FNTA (ABIN1882083)

Chiba, Sato, Misawa: "Upregulation of geranylgeranyltransferase I in bronchial smooth muscle of mouse experimental asthma: its inhibition by lovastatin." dans: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, Vol. 46, Issue 1, pp. 57-64, (2010) (PubMed).

Wang, Danielson, Li, Shah, Kim, Donahoe: "The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling." dans: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1120-2, (1996) (PubMed).

Zhang, Diehl, Kohl, Gibbs, Giros, Casey, Omer: "cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I." dans: The Journal of biological chemistry, Vol. 269, Issue 5, pp. 3175-80, (1994) (PubMed).

Andres, Milatovich, Ozçelik, Wenzlau, Brown, Goldstein, Francke: "cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences." dans: Genomics, Vol. 18, Issue 1, pp. 105-12, (1994) (PubMed).

Omer, Kral, Diehl, Prendergast, Powers, Allen, Gibbs, Kohl: "Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases." dans: Biochemistry, Vol. 32, Issue 19, pp. 5167-76, (1993) (PubMed).

Détails sur FNTA

Antigène: FNTA (Farnesyltransferase, CAAX Box, alpha (FNTA))

Autre désignation: FNTA (FNTA Produits)

Synonymes: anticorps ATFTA, anticorps FARNESYLTRANSFERASE A, anticorps FARNESYLTRANSFERASE SUBUNIT A, anticorps PFT/PGGT-IALPHA, anticorps PLP, anticorps PLURIPETALA, anticorps farnesyltransferase A, anticorps FPTA, anticorps PGGT1A, anticorps PTAR2, anticorps PFAS, anticorps FTA, anticorps farnesyltransferase A, anticorps farnesyltransferase, CAAX box, alpha, anticorps FTA, anticorps FNTA, anticorps Fnta

Sujet: FNTA, also known as CAAX farnesyltransferase (FTase), attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the so-called CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This type of posttranslational modification provides a mechanism for membrane localization of proteins that lack a transmembrane domain. This enzyme has the remarkable property of farnesylating peptides as short as four residues in length that conform to the CAAX consensus sequence. FNTA is also a specific cytoplasmic interactor of the transforming growth factor-beta and activin type I receptors. It is likely to be a key component of the signaling pathway which involves p21ras, an important substrate for farnesyltransferase.

Poids moléculaire: 44409

NCBI Accession: NP_002018

UniProt: P49354

Pathways: Response to Water Deprivation, Regulation of G-Protein Coupled Receptor Protein Signaling