GRK4 anticorps (C-Term)

N° du produit ABIN1882085

Détail du produit anti-GRK4 anticorps

Antigène: GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))

Épitope: AA 549-577, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRK4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This GRK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-577 amino acids from the C-terminal region of human GRK4.

Clone: RB0901

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-GRK4 (ABIN1882085)

Villar, Jones, Armando, Palmes-Saloma, Yu, Pascua, Keever, Arnaldo, Wang, Luo, Felder, Jose: "G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor." dans: The Journal of biological chemistry, Vol. 284, Issue 32, pp. 21425-34, (2009) (PubMed).

Perroy, Adam, Qanbar, Chénier, Bouvier: "Phosphorylation-independent desensitization of GABA(B) receptor by GRK4." dans: The EMBO journal, Vol. 22, Issue 15, pp. 3816-24, (2003) (PubMed).

Watanabe, Xu, Bengra, Jose, Felder: "Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4." dans: Kidney international, Vol. 62, Issue 3, pp. 790-8, (2002) (PubMed).

Sallese, Mariggiò, Collodel, Moretti, Piomboni, Baccetti, De Blasi: "G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells." dans: The Journal of biological chemistry, Vol. 272, Issue 15, pp. 10188-95, (1997) (PubMed).

Premont, Macrae, Stoffel, Chung, Pitcher, Ambrose, Inglese, MacDonald, Lefkowitz: "Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants." dans: The Journal of biological chemistry, Vol. 271, Issue 11, pp. 6403-10, (1996) (PubMed).

Sallese, Lombardi, De Blasi: "Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning." dans: Biochemical and biophysical research communications, Vol. 199, Issue 2, pp. 848-54, (1994) (PubMed).

Détails sur GRK4

Antigène: GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))

Autre désignation: GRK4 (GRK4 Produits)

Synonymes: anticorps GPRK2L, anticorps GPRK4, anticorps GRK4a, anticorps IT11, anticorps A830025H08Rik, anticorps GRK, anticorps Gprk2l, anticorps Gprk4, anticorps AMPK, anticorps AMPKalpha, anticorps CG3051, anticorps DmAMPK alpha, anticorps Dmel\\CG3051, anticorps EG:132E8.2, anticorps FBgn0023169, anticorps Gprk-4, anticorps ampk, anticorps ampkalpha, anticorps dAMPKa, anticorps dAMPKalpha, anticorps snf1a, anticorps gprk4, anticorps gprk4-a, anticorps grk4, anticorps GRK4, anticorps gprk4-b, anticorps zgc:153020, anticorps gprk2l, anticorps grk4a, anticorps it11, anticorps G protein-coupled receptor kinase 4, anticorps AMP-activated protein kinase alpha subunit, anticorps G protein-coupled receptor kinase 4 L homeolog, anticorps G protein-coupled receptor kinase 4 S homeolog, anticorps GRK4, anticorps Grk4, anticorps AMPKalpha, anticorps grk4.L, anticorps grk4.S, anticorps grk4, anticorps LOC100540688

Sujet: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

Poids moléculaire: 66583

NCBI Accession: NP_001004056, NP_001004057, NP_892027

UniProt: P32298

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling