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SHP1 anticorps (AA 247-277)

PTPN6 Reactivité: Humain WB, IF, IHC (p) Hôte: Lapin Polyclonal RB17225 unconjugated
N° du produit ABIN1882123
  • Antigène Voir toutes SHP1 (PTPN6) Anticorps
    SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
    Épitope
    • 35
    • 12
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 247-277
    Reactivité
    • 117
    • 73
    • 55
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 106
    • 13
    • 1
    Lapin
    Clonalité
    • 100
    • 20
    Polyclonal
    Conjugué
    • 55
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp SHP1 est non-conjugé
    Application
    • 81
    • 31
    • 22
    • 20
    • 20
    • 14
    • 14
    • 10
    • 9
    • 7
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This PTPN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-277 amino acids from the Central region of human PTPN6.
    Clone
    RB17225
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PTPN6 Anticorps primaire
  • Indications d'application
    IF: 1:100. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Korporaal, Koekman, Verhoef, van der Wal, Bezemer, Van Eck, Akkerman: "Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2." dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 29, Issue 3, pp. 372-9, (2009) (PubMed).

    Cho, Oh, Zhu: "Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation." dans: American journal of respiratory cell and molecular biology, Vol. 39, Issue 4, pp. 412-9, (2008) (PubMed).

  • Antigène
    SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
    Autre désignation
    PTPN6 (PTPN6 Produits)
    Synonymes
    anticorps HCPH, anticorps HPTP1C, anticorps PTP-1C, anticorps SH-PTP1, anticorps SHP-1, anticorps SHP-1L, anticorps SHP1, anticorps DRPLA, anticorps Hcph, anticorps Ptp1C, anticorps me, anticorps motheaten, anticorps Ptph6, anticorps Shp-1, anticorps fj22f05, anticorps wu:fj22f05, anticorps zgc:55501, anticorps ptpn6, anticorps protein tyrosine phosphatase, non-receptor type 6, anticorps protein tyrosine phosphatase, non-receptor type 6 L homeolog, anticorps PTPN6, anticorps Ptpn6, anticorps ptpn6, anticorps ptpn6.L
    Sujet
    PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.
    Poids moléculaire
    67561
    NCBI Accession
    NP_002822, NP_536858, NP_536859
    UniProt
    P29350
    Pathways
    Signalistation JAK/STAT, TCR Signaling, Signalisation TLR, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling
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