This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This SERPINA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-310 amino acids from the C-terminal region of human SERPINA3.
SERPINA3
Reactivité: Humain
IHC, ELISA
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:1000. FC: 1:10~50
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Baumann, Huber, Bode, Grosse, Lesjak, Laurell: "Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins." dans: Journal of molecular biology, Vol. 218, Issue 3, pp. 595-606, (1991) (PubMed).
Abraham, Shirahama, Potter: "Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin." dans: Neurobiology of aging, Vol. 11, Issue 2, pp. 123-9, (1990) (PubMed).
Antigène
SERPINA3
(serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3 (SERPINA3))
anticorps SERPINA3-1, anticorps Pi2, anticorps AACT, anticorps ACT, anticorps GIG25, anticorps A1AT, anticorps PI, anticorps alpha-1-PI, anticorps AAT, anticorps Pi, anticorps Spi1, anticorps SERPINA3-5, anticorps serpina3, anticorps serpin A3-5, anticorps serpin family A member 3, anticorps alpha-1-antiproteinase F precursor, anticorps serpin family A member 1, anticorps serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5, anticorps serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3, anticorps serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 L homeolog, anticorps LOC396684, anticorps SERPINA3, anticorps LOC100008973, anticorps SERPINA1, anticorps Serpina1, anticorps SPIA5, anticorps serpina3.L
Sujet
SERPINA3 is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.