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TK2 anticorps (N-Term)

TK2 Reactivité: Humain, Souris WB Hôte: Lapin Polyclonal RB5434 unconjugated
N° du produit ABIN1882141
  • Antigène Voir toutes TK2 Anticorps
    TK2 (Thymidine Kinase 2, Mitochondrial (TK2))
    Épitope
    AA 8-38, N-Term
    Reactivité
    Humain, Souris
    Hôte
    Lapin
    Clonalité
    Polyclonal
    Application
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This Thymidine Kinase 2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human Thymidine Kinase 2.
    Clone
    RB5434
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Antigène
    TK2 (Thymidine Kinase 2, Mitochondrial (TK2))
    Abstract
    TK2 Produits
    Synonymes
    anticorps MTDPS2, anticorps MTTK, anticorps AU024611, anticorps mt-TK, anticorps tk2, anticorps zgc:100948, anticorps thymidine kinase 2, mitochondrial, anticorps thymidine kinase 2, mitochondrial S homeolog, anticorps TK2, anticorps Tk2, anticorps tk2.S, anticorps tk2
    Sujet
    Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs. Both recombinant and native forms of the enzyme have broad substrate specificity and complex kinetics, suggesting that it may play a role in the activation of chemotherapeutic nucleoside analogs. The highest levels of expression are observed in testis and ovary. The main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis comes from the salvage pathway initiated by deoxyguanosine kinase (DGK) and TK2. The association of mitochondrial DNA depletion with mutations in the genes encoding these 2 kinases suggests that the salvage pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.
    Poids moléculaire
    31005
    NCBI Accession
    NP_001166114, NP_001166115, NP_001258864, NP_004605
    UniProt
    O00142
    Pathways
    Mitotic G1-G1/S Phases
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