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TYMS anticorps (C-Term)

Name: TYMS anticorps (C-Term)
SKU: ABIN1882144
Price: 445.5 EUR
Availability: InStock

TYMS Reactivité: Humain WB, IF, FACS, IHC (p) Hôte: Lapin Polyclonal RB20041 unconjugated

Western blot analysis of lysate from Jurkat cell line, using TYSY Antibody (C-term) (ABIN1882144 and ABIN2840937). (TYMS anticorps (C-Term))

Flow cytometric analysis of WiDr cells using TYSY Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). (TYMS anticorps (C-Term))

FACS

Confocal immunofluorescent analysis of TYSY Antibody (C-term) (ABIN1882144 and ABIN2840937) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (TYMS anticorps (C-Term))

Formalin-fixed and paraffin-embedded human colon carcinoma with TYSY Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (TYMS anticorps (C-Term))

IHC (p)

4 images

(3 références)

N° du produit ABIN1882144

Fiche de données

Antigène Voir toutes TYMS Anticorps

TYMS (Thymidylate Synthetase (TYMS))
Épitope
15

12

6

5

3

3

3

1

1

1

1

1
AA 265-294, C-Term
Reactivité
97

29

14

3

2

2

2

1

1

1
Humain
Hôte
54

42

1
Lapin
Anticorps secondaires appropriés
Clonalité
49

48
Polyclonal
Conjugué
45

7

4

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Cet anticorp TYMS est non-conjugé
Application
50

41

33

22

19

19

18

16

14

13

9

7

6

3

3

2

2

1

1
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène

This TYSY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human TYSY.

Clone

RB20041

Isotype

Ig Fraction

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anti-Thymidylate Synthetase (TYMS) (AA 111-210) antibody
TYMS Reactivité: Humain WB, IF, ELISA, IHC (p) Hôte: Souris Monoclonal 3A1 unconjugated

anti-Thymidylate Synthetase (TYMS) antibody
TYMS Reactivité: Humain WB, IF, IHC (p), IP, ICC Hôte: Lapin Polyclonal unconjugated

anti-Thymidylate Synthetase (TYMS) (AA 60-174) antibody
TYMS Reactivité: Humain WB, IF, FACS, IHC, ISt, RIA, StM Hôte: Souris Monoclonal TYMS-1884 unconjugated

anti-Thymidylate Synthetase (TYMS) antibody
TYMS Reactivité: Humain WB, IHC, IHC (p) Hôte: Souris Monoclonal 1D6 unconjugated

anti-Thymidylate Synthetase (TYMS) antibody
TYMS Reactivité: Humain WB, IHC, IHC (p) Hôte: Souris Monoclonal 5H8 unconjugated

anti-Thymidylate Synthetase (TYMS) (AA 111-210) antibody
TYMS Reactivité: Humain WB, ELISA, IHC (p), IP Hôte: Souris Monoclonal 2B2 unconjugated

anti-Thymidylate Synthetase (TYMS) (AA 2-54) antibody
TYMS Reactivité: Humain WB, IF, ELISA, IP Hôte: Lapin Polyclonal unconjugated

anti-Thymidylate Synthetase (TYMS) antibody
TYMS Reactivité: Humain, Souris, Rat IF Hôte: Lapin Polyclonal unconjugated

anti-Thymidylate Synthetase (TYMS) (AA 60-174) antibody
TYMS Reactivité: Humain IF, FACS, ELISA, RIA, Coat Hôte: Souris Monoclonal rTYMS-1884 unconjugated Recombinant Antibody

Indications d'application

IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions

For Research Use only
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

4 °C,-20 °C

Date de péremption

6 months
Ma, He, Zhang, Fei, Niu, Wang, Ding, Xu, Chen, Zhu: "DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression." dans: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5639-49, (2012) (PubMed).

Ren, Kim, Koh, Chang, Eom, Yi, Seong, Kim, Bronner, Cho: "Comparative analysis of thymidylate synthase at the protein, mRNA, and DNA levels as prognostic markers in colorectal adenocarcinoma." dans: Journal of surgical oncology, Vol. 100, Issue 7, pp. 546-52, (2009) (PubMed).

Schiffer, Clifton, Davisson, Santi, Stroud: "Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site." dans: Biochemistry, Vol. 34, Issue 50, pp. 16279-87, (1996) (PubMed).
Antigène

TYMS (Thymidylate Synthetase (TYMS))

Abstract

TYMS Produits

Synonymes

anticorps FN1, anticorps ECK2823, anticorps JW2795, anticorps ts, anticorps Ts, anticorps HST422, anticorps TMS, anticorps TS, anticorps thymidylate synthetase, anticorps contains intron in T4 phage, anticorps ThyE, anticorps thymidylate synthase, anticorps thymidylate synthetase L homeolog, anticorps TYMS, anticorps thyA, anticorps td, anticorps thyE, anticorps DDA3937_RS04960, anticorps tyms.L, anticorps XBJ1_RS15770, anticorps EAMY_RS20680, anticorps Tyms

Sujet

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

Poids moléculaire

35716

NCBI Accession

NP_001062

UniProt

P04818

Pathways

Mitotic G1-G1/S Phases