ATG3 anticorps (C-Term)

N° du produit ABIN1882157

Détail du produit anti-ATG3 anticorps

Antigène: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Épitope: AA 168-197, C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG3 est non-conjugé

Application: Western Blotting (WB)

Homologie: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ATG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human ATG3.

Clone: RB7459

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-ATG3 (ABIN1882157)

Radoshevich, Murrow, Chen, Fernandez, Roy, Fung, Debnath: "ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death." dans: Cell, Vol. 142, Issue 4, pp. 590-600, (2010) (PubMed).

Shintani, Klionsky: "Autophagy in health and disease: a double-edged sword." dans: Science (New York, N.Y.), Vol. 306, Issue 5698, pp. 990-5, (2004) (PubMed).

Détails sur ATG3

Antigène: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Autre désignation: ATG3 (ATG3 Produits)

Synonymes: anticorps atg3, anticorps im:6910145, anticorps wu:fb15g12, anticorps zgc:64156, anticorps APG3, anticorps APG3-LIKE, anticorps APG3L, anticorps PC3-96, anticorps 2610016C12Rik, anticorps Apg3l, anticorps Atg3l, anticorps PIG-1, anticorps Pig1, anticorps ATATG3, anticorps K11J9.1, anticorps K11J9_1, anticorps autophagy related 3, anticorps autophagy 3 (APG3), anticorps similar to S. cerevisiae ATG3 (YNR007C) part of ubiquitin-like system that mediates Atg8-phosphatidylethanolamine conjugation required for protein-vacuolar targeting and autophagy, anticorps atg3, anticorps ATG3, anticorps Atg3

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.

Poids moléculaire: 35864

NCBI Accession: NP_001265641, NP_071933

UniProt: Q9NT62

Pathways: Autophagy