ATG4D anticorps (N-Term)

N° du produit ABIN1882161

Détail du produit anti-ATG4D anticorps

Antigène: ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))

Épitope: AA 14-43, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG4D est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ATG4D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human ATG4D.

Clone: RB7563

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-ATG4D (ABIN1882161)

Williamson, Zhang, Colberg-Poley: "The human cytomegalovirus protein UL37 exon 1 associates with internal lipid rafts." dans: Journal of virology, Vol. 85, Issue 5, pp. 2100-11, (2011) (PubMed).

Li, Hou, Wang, Chen, Shao, Yin: "Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates." dans: The Journal of biological chemistry, Vol. 286, Issue 9, pp. 7327-38, (2011) (PubMed).

Baehrecke: "Autophagy: dual roles in life and death?" dans: Nature reviews. Molecular cell biology, Vol. 6, Issue 6, pp. 505-10, (2005) (PubMed).

Lum, DeBerardinis, Thompson: "Autophagy in metazoans: cell survival in the land of plenty." dans: Nature reviews. Molecular cell biology, Vol. 6, Issue 6, pp. 439-48, (2005) (PubMed).

Greenberg: "Degrade or die: a dual function for autophagy in the plant immune response." dans: Developmental cell, Vol. 8, Issue 6, pp. 799-801, (2005) (PubMed).

Levine: "Eating oneself and uninvited guests: autophagy-related pathways in cellular defense." dans: Cell, Vol. 120, Issue 2, pp. 159-62, (2005) (PubMed).

Shintani, Klionsky: "Autophagy in health and disease: a double-edged sword." dans: Science (New York, N.Y.), Vol. 306, Issue 5698, pp. 990-5, (2004) (PubMed).

Détails sur ATG4D

Antigène: ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))

Autre désignation: ATG4D (ATG4D Produits)

Synonymes: anticorps APG4-D, anticorps APG4D, anticorps AUTL4, anticorps 9830134P12Rik, anticorps Apg4d, anticorps Atg4dl, anticorps Autl4, anticorps apg4d, anticorps autophagy related 4D cysteine peptidase, anticorps autophagy related 4D, cysteine peptidase, anticorps autophagy related 4D, cysteine peptidase L homeolog, anticorps ATG4D, anticorps Atg4d, anticorps atg4d.L

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4 is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Poids moléculaire: 52922

NCBI Accession: NP_001268433, NP_116274

UniProt: Q86TL0

Pathways: Autophagy