Phospholamban anticorps (N-Term)

N° du produit ABIN1882182

Détail du produit anti-Phospholamban anticorps

Antigène: Phospholamban (PLN)

Épitope: AA 1-22, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Phospholamban est non-conjugé

Application: Western Blotting (WB)

Homologie: B, M, Pig, Rb, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PLN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-22 amino acids from the N-terminal region of human PLN.

Clone: RB44799

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-Phospholamban (ABIN1882182)

Kaliman, Catalucci, Lam, Kondo, Gutiérrez, Reddy, Palacín, Zorzano, Chien, Ruiz-Lozano: "Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum." dans: The Journal of biological chemistry, Vol. 280, Issue 9, pp. 8016-21, (2005) (PubMed).

Minamisawa, Sato, Tatsuguchi, Fujino, Imamura, Uetsuka, Nakazawa, Matsuoka: "Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy." dans: Biochemical and biophysical research communications, Vol. 304, Issue 1, pp. 1-4, (2003) (PubMed).

McTiernan, Frye, Lemster, Kinder, Ogletree-Hughes, Moravec, Feldman: "The human phospholamban gene: structure and expression." dans: Journal of molecular and cellular cardiology, Vol. 31, Issue 3, pp. 679-92, (1999) (PubMed).

Fujii, Zarain-Herzberg, Willard, Tada, MacLennan: "Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6." dans: The Journal of biological chemistry, Vol. 266, Issue 18, pp. 11669-75, (1991) (PubMed).

Détails sur Phospholamban

Antigène: Phospholamban (PLN)

Autre désignation: PLN (PLN Produits)

Synonymes: anticorps LOC100226261, anticorps plb, anticorps cmd1p, anticorps CMD1P, anticorps CMH18, anticorps PLB, anticorps Plb, anticorps Plm, anticorps phospholamban, anticorps PLN, anticorps pln, anticorps Pln

Sujet: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2 Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

Poids moléculaire: 6109

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity