STK3 anticorps (AA 228-252)

N° du produit ABIN1882187

Détail du produit anti-STK3 anticorps

Antigène: STK3 (serine/threonine Kinase 3 (STK3))

Épitope: AA 228-252

Reactivité: Humain, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STK3 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This DANRE stk3(36kDa subunit) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 228-252 amino acids from the Central region of DANRE stk3(36kDa subunit).

Clone: RB47395

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur STK3

Antigène: STK3 (serine/threonine Kinase 3 (STK3))

Autre désignation: stk3 (STK3 Produits)

Synonymes: anticorps KRS1, anticorps MST2, anticorps 0610042I06Rik, anticorps MST, anticorps Mst2, anticorps Mst3, anticorps Ste20, anticorps mess1, anticorps mst2, anticorps xstk3, anticorps wu:fc19e11, anticorps zgc:55383, anticorps serine/threonine kinase 3, anticorps serine/threonine kinase 3 S homeolog, anticorps serine/threonine kinase 3 (STE20 homolog, yeast), anticorps STK3, anticorps Stk3, anticorps stk3.S, anticorps stk3

Sujet: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (By similarity).

Poids moléculaire: 56081

UniProt: Q7ZUQ3

Pathways: Tube Formation