HLA-DR Beta anticorps (AA 1-262)

N° du produit ABIN1885860

Détail du produit anti-HLA-DR Beta anticorps

Antigène: HLA-DR Beta (HLA-DRB) (Major Histocompatibility Complex, Class II, DR beta (HLA-DRB))

Épitope: AA 1-262

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-DR Beta est non-conjugé

Application: Western Blotting (WB)

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 262 of Human HLA-DRB4

Information d'application

Indications d'application: Suggested dilutions:
Western blotting: 1.500-1.3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: Biohazard Informations: This product contains thimerosal which is hazardous.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur HLA-DR Beta

Antigène: HLA-DR Beta (HLA-DRB) (Major Histocompatibility Complex, Class II, DR beta (HLA-DRB))

Abstract: HLA-DRB Produits

Sujet: HLA-DRB4 belongs to the HLA class II beta chain paralogues.This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane.It plays a central role in the immune system by presenting peptides derived from extracellular proteins.Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).The beta chain is approximately 26-28 kDa and its gene contains 6 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities.Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5.The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted.There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.[provided by RefSeq]

Poids moléculaire: 30 kDa

ID gène: 3126

NCBI Accession: NM_021983, NP_068818