DR4 anticorps (AA 1-20)

N° du produit ABIN1886840

Détail du produit anti-DR4 anticorps

Antigène: DR4 (Drought-Repressed 4 Protein (DR4))

Épitope: AA 1-20

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DR4 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée (Details): DR4 antibody has no cross reaction to DR5.

Purification: Purified by DEAE column

Immunogène: Peptide corresponding to amino acid 1 to 20 of human DR4 mature protein.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur DR4

Antigène: DR4 (Drought-Repressed 4 Protein (DR4))

Autre désignation: DR4 (DR4 Produits)

Synonymes: anticorps APO2, anticorps CD261, anticorps DR4, anticorps TRAILR-1, anticorps TRAILR1, anticorps TNF receptor superfamily member 10a, anticorps TNFRSF10A

Sujet: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms.Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas.A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4).The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family.DR4 is also called TRAIL receptor-1 (TRAIL-R1).DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus.Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kappaB activation in many tissues and cells.
Synonyms: TRAIL-R1

Poids moléculaire: 57 kDa

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity