SPINK7
Reactivité: Humain, Souris
WB, IF (cc), IF (p)
Hôte: Lapin
Polyclonal
AbBy Fluor® 350
Restrictions
For Research Use only
Format
Liquid
Buffer
PBS containing 0.02 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Conseil sur la manipulation
Avoid freezing and thawing repeatly.
Stock
4 °C/-20 °C
Stockage commentaire
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
Antigène
SPINK7/ECRG2 (SPINK7)
(Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))
The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus.It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis.ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion.ECRG2 may thus represent a novel therapeutic target for cancer. Synonyms: Esophageal cancer-susceptibility gene 2 protein, ECG2, serine protease inhibitor Kazal-type 7, SPINK7