WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Conseil sur la manipulation
Avoid freezing and thawing repeatly.
Stock
4 °C/-20 °C
Stockage commentaire
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
Antigène
DNAJC13
(DnaJ heat shock protein family (Hsp40) member C13 (DNAJC13))
anticorps RME8, anticorps D030002L11Rik, anticorps Gm1124, anticorps RME-8, anticorps Rme8, anticorps mKIAA0678, anticorps DnaJ heat shock protein family (Hsp40) member C13, anticorps dnaJ homolog subfamily C member 13, anticorps DNAJC13, anticorps LOC100167963, anticorps LOC100640734, anticorps Dnajc13
Sujet
DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C.elegans.It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system.Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles.DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor. Synonyms: DNAJ homolog subfamily C member 13, receptor-mediated endocytosis 8, RME8