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CD13 anticorps (FITC)

ANPEP Reactivité: Humain, Non-Human Primate FACS Hôte: Souris Monoclonal WM15 FITC
N° du produit ABIN192304
  • Antigène Voir toutes CD13 (ANPEP) Anticorps
    CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))
    Reactivité
    • 142
    • 55
    • 22
    • 9
    • 7
    • 7
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    Humain, Non-Human Primate
    Hôte
    • 93
    • 58
    • 17
    • 1
    • 1
    Souris
    Clonalité
    • 115
    • 52
    Monoclonal
    Conjugué
    • 71
    • 18
    • 17
    • 11
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD13 est conjugé à/à la FITC
    Application
    • 111
    • 53
    • 38
    • 33
    • 33
    • 30
    • 20
    • 17
    • 17
    • 14
    • 13
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The antibody WM15 recognises an extracellular epitope of human CD13 cell surface glycoprotein, a 150 kDa molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors.
    Réactivité croisée (Details)
    Human, Non-Human Primates
    Purification
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Human AML cells
    Clone
    WM15
    Isotype
    IgG1
    Top Product
    Discover our top product ANPEP Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • McCormack, Muji?, Osdal, Bruserud, Gjertsen: "Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia." dans: Blood, Vol. 121, Issue 7, pp. e34-42, (2013) (PubMed).

    Favaloro, Browning, Facey: "CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated." dans: Experimental hematology, Vol. 21, Issue 13, pp. 1695-701, (1993) (PubMed).

    Bradstock, Favaloro, Kabral, Kerr, Hughes, Berndt, Musgrove: "Human myeloid differentiation antigens identified by monoclonal antibodies: expression on leukemic cells." dans: Pathology, Vol. 17, Issue 3, pp. 392-9, (1986) (PubMed).

    Bradstock, Favaloro, Kabral, Kerr, Hughes, Musgrove: "Myeloid progenitor surface antigen identified by monoclonal antibody." dans: British journal of haematology, Vol. 61, Issue 1, pp. 11-20, (1985) (PubMed).

  • Antigène
    CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))
    Autre désignation
    CD13 (ANPEP Produits)
    Sujet
    Alanyl aminopeptidase, membrane,CD13 (aminopeptidase N, APN) is a 150 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. This metalloprotease preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 has also role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas.,Aminopeptidase N, APN, PEPN, ANPEP, gp150, LAP1
    ID gène
    290
    UniProt
    P15144
    Pathways
    Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones
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